Keywords Methods; Maceration; Soxhlet extraction; Microwaveassisted extraction, Ultrasound-assisted extraction, Accelerated solvent extraction, Supercritical-fluid extraction, Medicinal plants Introduction Medicinal plants are currently in considerable significance view due to their special attributes as a large source of therapeutic phytochemicals that may lead to the development of novel drugs. Most of the phytochemicals from plant sources such as phenolics and flavonoids have been reported to have positive impact on health and cancer prevention . Modern Mediterranean and DASH (Dietary Approaches to Stop Hypertension) incorporate a phytochemicals rich diet from fruit and vegetable sources as the plant based diet has shown to extend life span in Okinawan people, that has the highest number of centenarians [2,3]. Interest in utilizing natural sources in the development and formulation of skin products, as an alternative to conventional drugs and synthetic products, contribute to increase interest in research and industrial application of medicinal plants . High content of phenolic and flavonoids in medicinal plants have been associated with their antioxidant activities that play a role in the prevention of the development of age-related disease, particularly cause by oxidative stress. With regards to the beneficial phytochemicals in medicinal plants and the shift towards natural products in pharmaceuticals and cosmeceuticals industry, the research on medicinal plants particularly are as important as the research on conventional drugs. The study of medicinal plants starts with the pre-extraction and the extraction procedures, which is an important step in the processing of the bioactive constituents from plant materials. Traditional methods such as maceration and Soxhlet extraction are commonly used at the small research setting or at Small Manufacturing Enterprise (SME) level. Significance advances have been made in the processing of medicinal plants such as the modern extraction methods; microwave-assisted (MAE), ultrasound-assisted extraction (UAE) and supercritical fluid extraction (SFE), in which these advances are aimed to increase yield at lower cost. Moreover, modifications on the methods are continuously developed. With such variety of methods present, selection of proper extraction method needs meticulous evaluation. This review describes the principle, strength and limitation of the commonly used methods with examples in recent years to help in the selection of proper methods.